Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis

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Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis

Hydrogen sulfide (H2S) is a gasotransmitter which regulates multiple cardiovascular functions. However, the precise roles of H2S in modulating myocardial fibrosis in vivo and cardiac fibroblast proliferation in vitro remain unclear. We investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial fibrosis. Spontaneously hypertensive rats (SHR) were administrated with GYY4137 by ...

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ژورنال

عنوان ژورنال: Oxidative Medicine and Cellular Longevity

سال: 2015

ISSN: 1942-0900,1942-0994

DOI: 10.1155/2015/691070